'Indian highways completion is h…

New Delhi: Despite exte…

CBI charges five more in Jindal …

  New Delhi: The Central…

Warm Friday morning in Delhi

  New Delhi: It was a wa…

Hurdles notwithstanding, Akshaya…

Book: Gods Own Kitchen;…

Not just 'Adarsh Bhartiya Nari',…

  New Delhi: He is the a…

Three Maoists killed in Jharkhan…

  Ranchi: Three Maoists …

Unpaid for months, veteran Benga…

Kolkata:  A veteran physi…

Draft TB control plan targets fe…

A radical draft National …

Air India flight grounded in Lon…

Ahmedabad/London:  Nation…

India's UN connect: A treasured …

New Delhi:  This one sure…

«
»
TwitterFacebookPinterestGoogle+

Gene that quells desire to drink alcohol identified

Facebooktwittergoogle_plusredditpinterestlinkedinmail

New York: In a step that could lead to development of drugs to regulate alcohol consumption, researchers have identified a gene variant that suppresses the desire for a drink.

“The findings are based on the largest genome-wide association meta-analysis and replication study to date mapping and comparing the genetics — the DNA — of more than 105,000 light and heavy social drinkers,” said corresponding author of the study David Mangelsdorf, Chair of Pharmacology at University of Texas Southwestern Medical Center.

“The study identified a variation in the beta-Klotho gene linked to the regulation of social alcohol consumption. The less frequent variant — seen in approximately 40 per cent of the people in this study — is associated with a decreased desire to drink alcohol,” he said.

Like many complex traits, the genetic influences on brain functions affecting drinking behaviour were thought to be so small that it would be necessary to study large numbers of people in order to detect those genetic variations, Mangelsdorf said.

The study compared the genetics of light and heavy social drinkers of European ancestry participating in nearly four dozen other large population studies worldwide.

The findings, published online in the journal Proceedings of the National Academy of Sciences (PNAS), could lead to development of drugs to help those with drinking problems.

A shift from heavy to moderate social drinking could have major public health benefits, such as reduced cardiovascular disease risk.

Increased alcohol consumption is linked to two heart disease risk factors in particular — high blood pressure and obesity, according to the American Heart Association.

Leave a Reply

Your email address will not be published. Required fields are marked *

CAPTCHA Image

*

Sections

Shows

Other News

About Us

Follow Us